Losonczy Lab

Department of Neuroscience at Columbia University Medical Center

Lab Publications:

Research Articles:

Danielson N, Turi GF, Ladow M, Chavlis M, Petrantonakis PC, Poirazi P, and Losonczy A. In vivo imaging of dentate gyrus mossy cells in behaving mice. Neuron, 2017

Lewis TL, Turi GF, Kwon SK, Losonczy A, and Polleux. Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo. Current Biology, 2016

Danielson N, Zaremba J, Kaifosh P, Bowler J, Ladow, M, and Losonczy A. Sublayer-sneuron_91_3_4cpecific coding dynamics during spatial navigation and learning in hippocampal area CA1. Neuron, 2016

Kaifosh P, and Losonczy A. Mnemonic functions for nonlinear integration of laminar inputs by hippocampal pyramidal cells. Neuron, 2016, 90, 1-13

Danielson N, Zaremba JD, Kaifosh P, Lovett-Barron M, Tsai J, Denny CA, Balough ME, Cloidt MA, Drew JD, Hen R, Losonczy A*, and Kheirbek MA. Distinct contribution of adult-born hippocampal granule cells to context encoding. Neuron, 2016

Reardon, TR, Murray AJ, Turi GF, Wirblich C, Croce K, Schnell MJ, Jessell TM, and Losonczy A (2016). Rabies virus CVS-N2cΔG strain enhances synaptic transfer, neuronal viability and circuit analysis. Neuron, 2016 Feb 17;89(4):711-24. doi: 10.1016/j.neuron.2016.01.004. Epub 2016 Jan 21

Basu J, Zaremba JD, Cheung SK, Hitti FL, Zemelman BV, Losonczy A, and Siegelbaum SA. Tuning hippocampal activity, sensory coding and learning behavior with entorhinal cortex long-range inhibition (2016). Science, Vol. 351 no. 6269 DOI: 10.1126/science.aaa5694

Turi GF, Wittmann G, Lechan MR, and Losonczy A. Ambient GABA modulates septo-hippocampal inhibitory terminals via presynaptic GABAb receptors. Neuropharmacology, 2015  2015 Jan;88:55-62

Kaifosh P, Zaremba J, Danielson N, and Losonczy A. SIMA: Python software for analysis of dynamic fluorescence imaging data. Frontiers in Neuroinformatics. 2014 Aug 27; 8:77. doi: 10.3389/fninf.2014.00077.

Denny, CA, Kheirbek, MA, Alba, E., Tanaka, KF, Brachman, RA, Laughman, KB, Tomm, NK, Turi, GF, Losonczy, A, and Hen, R. (2014). Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron, 2014 July2, doi: 10.1016/j.neuron.2014.05.018.

Lee, S-H., Marchionni, I., Bezaire, M., Varga, C., Danielson, N., Lovett-Barron, M., Losonczy, A., and Soltesz, I. (2014). Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron, 2014 May 14. doi: 10.1016/j.neuron.2014.03.034. [Epub ahead of print].
Video abstract

Lovett-Barron M, Kaifosh P, Kheirbek, MA, Danielson, N. Zaremba, JD, Reardon, TR, Turi FG, Hen R, Zemelman, BV and Losonczy A. Dendritic inhibition in the hippocampus supports fear learning. Science, 2014 Feb 21; 343(6173):857-63. doi: 10.1126/science.1247485.

Kaifosh P, Lovett-Barron M, Turi GF, Reardon TR and Losonczy A. Septo-hippocampal GABAergic signaling across multiple modalities in awake mice. Nat Neurosci. 2013 Sep;16(9):1182-4. doi: 10.1038/nn.3482

Nat Neurosci CoverLovett-Barron M, Turi GF, Kaifosh P, Lee PH, Bolze F, Sun XH, Nicoud JF, Zemelman BV, Sternson SM and Losonczy A. Regulation of neuronal input transformations by tunable dendritic inhibiton. Nat Neurosci. 2012 Jan 15;15(3):423-30, S1-3. doi: 10.1038/nn.3024

News and Views. Oren I and Kullmann D. Mapping out hippocampal inhibition Nat Neurosci. 2012 Feb 24;15(3):346-7. doi: 10.1038/nn.3056.





Kaifosh, P. and Losonczy, A (2014) The inside track: privileged neural communication through axon-carrying dendrites. Neuron, 83,1231-1234.

Piant S, Specht A, Zemelman B, Losonczy A, and Bolze, F.  (2014) Two-photon sensitive photolabile protecting groups: From molecular engineering to nanostructuration. Biomedical Optics, doi.org/10.1364/BIOMED.2014.BT3A.33

Lovett-Barron M and Losonczy,A. (2014). Behavioral consequences of GABAergic neuronal diversity. Current Opinion in Neurobiology, 26, 27-33.

Lovett-Barron M and Losonczy A. Circuits supporting the grid (2013). Nat Neurosci., 16:255-7.
Comment on:
Recurrent inhibitory circuitry as a mechanism for grid formation. Nat Neurosci. 2013
Grid cells require excitatory drive from the hippocampus. Nat Neurosci. 2013

Bolze, F., Nicoud J.F., Bourgogne, C., Gug, S., Sun, X.H., Goeldner, M., Specht, A., Donato, L., Warther, D., Turi, G.F., and Losonczy, A. (2012). Two-photon uncaging: the chemist point of view. Optical Materials, 34, 1664-1669.

Representative Previous Publications of the PI

Royer S, Zemelman BV, Losonczy A, Kim J, Chance F, Magee JC and Buzsáki G. Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition. Nat Neurosci. 2012 Mar 25;15(5):769-75. doi 10.1038/nn.3077

Losonczy A, Zemelman BV, Vaziri A and Magee JC. Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons. Nat Neurosci. 2010 Aug;13(8):967-72. doi:10.1038/nn.2597

Makara JK, Losonczy A, Wen Q and Magee JC. Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons. Nat Neurosci. 2009 Dec;12(12):1485-7. doi:10.1038/nn.2428

Varga V, Losonczy A, Zemelman B, Borhegyi Z, Nyiri G, Domonkos G, Hangya B, Holderith B, Magee JC and Freund TF. Fast synaptic subcortical control of hippocampal circuits. Science. 2009 Oct 16;326(5951):449–53. doi:10.1126/science.1178307

Losonczy A, Makara JK and Magee JC. Compartmentalized dendritic plasticity and input feature storage in neurons. Nature. 2008 Mar 27;452, 436-41. doi:10.1038/nature06725

Losonczy A, Magee JC. Integrative properties of radial oblique dendrites in hippocampal CA1
pyramidal neurons. Neuron. 2006 Apr 20;50(2):291-307.

Losonczy A, Biró AA, Nusser Z. Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1362-7.